6-METHYL-2(PROPANE-1-SULFONYL)-2H-THIENO[3,2-D][1,2,3]DIAZABORININ-1-OL

6-METHYL-2(PROPANE-1-SULFONYL)-2H-THIENO[3,2-D][1,2,3]DIAZABORININ-1-OL is a boron-containing heterocyclic compound, specifically a sulfonylated diazaborine derivative with the molecular formula C₉H₁₃BN₂O₃S₂ and an average molecular mass of 272.146 g/mol. Its structure comprises a thieno-diazaborine core fused with a sulfonylpropane substituent and a methyl group. The compound is characterized by a boronate ester linkage, which confers unique electronic and steric properties critical for its biological activity. It acts as a potent inhibitor of bacterial enoyl-acyl carrier protein (ACP) reductase (ENR), a key enzyme in bacterial fatty acid biosynthesis. This inhibition disrupts the synthesis of bacterial cell membranes, leading to bacterial cell death. Due to this mechanism, it is being explored for potential therapeutic applications as an antibacterial agent, particularly against resistant strains of bacteria.

Other names

1,2-Dihydro-1-hydroxy-6-methyl-2-(propanesulfonyl)-thieno(3,2D)(1,2,3)-diazaborine1-hydroxy-6-methyl-2-propylsulfonylthieno[3,2-d]diazaborinineDiazaborine compound 2b18Thieno(3,2-d)(1,2,3)diazaborine, 1,2-dihydro-1-hydroxy-6-methyl-2-(propylsulfonyl)-6-methyl-2-(propane-1-sulfonyl)-1H,2H-thieno[3,2-d][1,2,3]diazaborinin-1-ol